Bacterial metabolites modulating Immune Function

The Moonwalk Project

by Carlotta Bilger | Dec 2, 2024

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The Moonwalk Project

Investigating the relationship between glucose values and motion patterns during sleep

Glucose Levels and Sleep Patterns

People with diabetes need to carefully control their blood sugar levels to avoid short and long-term health complications. This can be done using insulin injections, but it also increases the risk of low blood sugar, called hypoglycaemia. Hypoglycaemia often occurs at night and can lead to serious problems such as falls and heart problems. It can also reduce quality of life and cause symptoms like shaking, abnormal breathing, and abnormal movements. Managing diabetes can be especially difficult for elderly people in long-term care due to other health conditions and changes in care providers. The Moonwalk project aims to investigate the possible association between glucose levels and motion patterns during sleep in people with diabetes. To achieve this, a QUMEA radar sensor is mounted on the ceiling to track motion during sleep, and wrist-worn smartwatches are used to collect data on physiological symptoms. Over the course of 10 days, data will be collected from 40 patients. After the end of the study, algorithms will be developed to build a warning system for nocturnal hypoglycaemia.

Project team: Prof. Lilian Witthauer, Prof. Markus Laimer, QUMEA AG

Funding: Diabetes Center Berne Foundation, Innosuisse Innovation Cheque, Von-Tobel Foundation

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Illuminating Personalized Medicine

by Carlotta Bilger | Dec 2, 2024

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Illuminating Personalized Medicine

Porphyrin-based Aggregation-induced Emission Generating Molecules for Continuous Multi-Metabolite Monitoring

Personialized Medicine Study

In this project, a new sensor technology is being developed to improve the monitoring of multiple metabolites. Special molecules with aggregation-induced emission, known as AIEgens, are utilized, which emit particularly bright luminescence upon aggregation. These AIEgens are designed to emit light in different spectral regions, enabling the simultaneous measurement of various metabolites such as glucose, lactate, and ketones. Integrated into a biocompatible matrix and applied to the tip of an optical sensor, which is incorporated into a wearable device, this minimally invasive system allows for continuous monitoring of metabolism in the interstitial fluid under the skin. This technology has the potential to significantly improve diagnosis and personalized treatment for conditions like diabetes and cardiovascular diseases.

Project team: Prof. Lilian Witthauer, Dr. Emmanouil Rousakis

Funding: Swiss National Science Foundation

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Volatile Organic Compounds in Breath

by Carlotta Bilger | Dec 2, 2024

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Volatile Organic Compounds in Breath

Volatile organic compounds and breath analysis in people with diabetes

Breath analysis in individuals with diabetes

The main goal of this research area is to identify distinctive patterns of Volatile Organic Compounds (VOCs)s in breath and their dependence on blood glucose values in individuals with diabetes. VOCs are emitted by the human body, among which breath is the most important carrier. The breath contains a diverse array of VOCs that offer valuable insights into the body’s metabolic activities, including the glucose metabolism.

Project team: Prof. Lilian Witthauer, Prof. Markus Laimer

Funding: Diabetes Center Berne, University of Bern

Publications:
Nicolier C, Künzler J, Lizoain A, et al. Detection of hypoglycaemia in type 1 diabetes through breath volatile organic compound profiling using gas chromatography–ion mobility spectrometry. Diabetes Obes Metab. 2024; 1-8. doi:10.1111/dom.15944

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enhance-d: Enhanced Diabetes Self-Management

by Svea Krutisch | Sep 7, 2023

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enhance-d: Enhanced Diabetes Self-Management

Diabetes technology generates a lot of data, but rarely is all this data used to inform action. DCB supports enhance-d in combining real-time diagnostics across every aspect of the digital diabetes experience with AI-powered analytics and visualisations to see, diagnose and explain glucose self-management.

Making Sense of Diabetes Data to Inform Self-Management

Diabetes management is influenced by many different factors at all times, including nutrition and exercise. Advances in technology are making data capture of all factors easier than ever before – but how can people with diabetes inform their actions based on this huge amount of data?

enhance-d combines real-time diagnostics across every aspect of the digital diabetes experience with AI-powered analytics and user-friendly visualisations to see, diagnose and explain glucose management. Based on the team’s previous experience working with professional athletes with diabetes, they are familiar with the challenge of creating optimal training plans considering all influencing factors. With enhance-d, their goal was to develop a solution that could generate a simplified overview for everyone, whether professional athletes or individuals simply starting regular exercise.

_enhance-d pitch deck 2023_VK Stage 2 Camp__001

enhance-d stands for improved self-management for people with diabetes using a simple digital solution. CGM and other portable data allows an understanding of how pharmacologic, behavioural, dietary and activity-based interventions contribute to changes in glucose profiles – and how users can take action based on these findings.

Project Team: Federico Fontana (Founder & CEO), Sam Scott (Founder & CSO), Fabio Saviozzi (Founder & CCO), Felipe Mattioni Maturana (Founder & CTO).

Project support: DCB supports enhance-d financially with 150’000 CHF as well as with access to our network of experts and our knowledge in product development.

enhance-d founders Fabio Saviozzi, Sam Scott, Federico Fontana and Felipe Mattioni Maturana

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DCB Research AG

Freiburgstrasse 3
3010 Bern
Schweiz