{"id":10297,"date":"2025-01-28T13:59:09","date_gmt":"2025-01-28T13:59:09","guid":{"rendered":"https:\/\/www.dcberne.com\/?post_type=project&#038;p=10297"},"modified":"2025-05-07T13:34:23","modified_gmt":"2025-05-07T13:34:23","slug":"aid-junct-study-gip-glp-1ra-as-adjunctive-to-automated-insulin-delivery-in-type-1-diabetes","status":"publish","type":"project","link":"https:\/\/www.dcberne.com\/en\/project\/aid-junct-study-gip-glp-1ra-as-adjunctive-to-automated-insulin-delivery-in-type-1-diabetes\/","title":{"rendered":"AID-JUNCT study: GIP\/GLP-1RA as Adjunctive to Automated Insulin Delivery"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;1px||0px||false|false&#8221; custom_margin_tablet=&#8221;1px||0px||false|false&#8221; custom_margin_phone=&#8221;3px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; 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meta_line_height=&#8221;16px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||20px||false|false&#8221; custom_css_post_meta=&#8221;text-transform: uppercase;&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_post_title author=&#8221;off&#8221; date_format=&#8221;j \u00b7 M \u00b7 Y&#8221; comments=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.27.3&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;Avant Regular||||||||&#8221; title_text_color=&#8221;#000000&#8243; title_font_size=&#8221;64px&#8221; title_line_height=&#8221;70px&#8221; meta_font=&#8221;Avant Regular||||||||&#8221; meta_text_color=&#8221;#000000&#8243; meta_font_size=&#8221;14px&#8221; meta_line_height=&#8221;24px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||16px||false|false&#8221; title_font_size_tablet=&#8221;&#8221; title_font_size_phone=&#8221;42px&#8221; title_font_size_last_edited=&#8221;on|phone&#8221; title_line_height_tablet=&#8221;&#8221; title_line_height_phone=&#8221;48px&#8221; title_line_height_last_edited=&#8221;on|phone&#8221; custom_css_post_meta=&#8221;text-transform: uppercase;&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;24px&#8221; link_text_color=&#8221;#89BBE5&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Findings from a prospective, randomized clinical study<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; module_id=&#8221;post-content&#8221; _builder_version=&#8221;4.27.3&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;589px&#8221; custom_margin=&#8221;30px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;30px&#8221; text_line_height=&#8221;36px&#8221; link_font=&#8221;||||on|||#89BBE5|&#8221; link_text_color=&#8221;#89BBE5&#8243; custom_margin=&#8221;0px|-36px|0px||false|false&#8221; custom_padding=&#8221;0px||16px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Innovative approaches to combination therapy in type 1 Diabetes<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text ul_item_indent=&#8221;20px&#8221; ol_item_indent=&#8221;20px&#8221; module_id=&#8221;post-body&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;24px&#8221; link_font=&#8221;||||on|||#89BBE5|&#8221; link_text_color=&#8221;#89BBE5&#8243; width=&#8221;100%&#8221; min_height=&#8221;67px&#8221; custom_margin=&#8221;0px||80px||false|false&#8221; custom_margin_tablet=&#8221;0px||80px||false|false&#8221; custom_margin_phone=&#8221;||48px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px|0px|0px||false|false&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><span>Glycemic control in type 1 diabetes (T1D) remains a challenge, with ~32% of adults in Switzerland achieving an A1c target of &lt;7%. The dual glucagon-like peptide-1 receptor agonists (GLP-1RAs) and glucose-dependent insulinotropic polypeptide (GIP)\/GLP-1RAs has emerged as promising therapy in T1D. Retrospective studies have shown people with T1D can significantly improve glycemic control with a reduction in insulin dose and body weight when long-acting GLP-1RAs or GIP\/GLP-1RAs are added to insulin therapy. <\/span><span><\/span><\/p>\n<p><span>This study will assess glycemic control in people with T1D on a stable dose of long-acting GIP\/GLP-1RA (<\/span><span>Tirzepatide<\/span><span>) as an adjuvant therapy to automated insulin delivery (AID). We are conducting a prospective, parallel, open-label, randomized clinical trial to test the hypothesis that available AID systems combined with GIP\/GLP-1RA will lead to safe and more efficacious glycemic control than Standard of Care (SoC) during the assessment period. The outcome of this study will provide unique data about the safety and efficacy of using GIP\/GLP1-RA as adjuvant therapy to AID systems. <\/span><\/p>\n<p><span style=\"font-size: 18px;\"><br \/><strong>Sponsor:<\/strong> Prof. Jos\u00e9 Garc\u00eda-Tirado, PhD \u2013 University of Berne<br \/><\/span><span style=\"font-weight: 400;\"><strong>Principal investigator:<\/strong> PD Dr. med. Thomas Z\u00fcger, Chief Physician \u2013 Kantonsspital Olten<br \/><strong>PhD student:<\/strong> <span data-teams=\"true\">Dr. med. Maria Carolina Fragozo-Ramos <\/span><br \/><strong>Funding:<\/strong> Internal funds<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><\/span><span style=\"font-weight: 400;\"><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/01\/2-2-e1738071791559.png&#8221; title_text=&#8221;2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;95.7%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FAFAFA&#8221; custom_margin=&#8221;0px||120px||false|false&#8221; custom_margin_tablet=&#8221;0px||120px||false|false&#8221; 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custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>More recent projects<\/p>\n<p>[\/et_pb_text][et_pb_blog fullwidth=&#8221;off&#8221; post_type=&#8221;project&#8221; posts_number=&#8221;3&#8243; meta_date=&#8221;j \u00b7 M \u00b7 Y&#8221; excerpt_length=&#8221;120&#8243; show_author=&#8221;off&#8221; show_pagination=&#8221;off&#8221; masonry_tile_background_color=&#8221;RGBA(255,255,255,0)&#8221; module_class=&#8221;dcb-news&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;Avant Regular||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;20px&#8221; header_line_height=&#8221;24px&#8221; body_font=&#8221;Calibri Regular||||||||&#8221; body_text_color=&#8221;#505358&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;22px&#8221; meta_font=&#8221;Calibri Regular||||||||&#8221; meta_font_size=&#8221;10px&#8221; meta_line_height=&#8221;16px&#8221; pagination_text_color=&#8221;#89BBE5&#8243; 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The dual glucagon-like peptide-1 receptor agonists (GLP-1RAs) and glucose-dependent insulinotropic polypeptide (GIP)\/GLP-1RAs has emerged as promising therapy in T1D. [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":10350,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"give_campaign_id":0,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[62,50,59,47],"project_tag":[],"class_list":["post-10297","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-commitment-clinical-studies","project_category-digital-diabetes","project_category-commitment-research-projects","project_category-commitment-technology-projects"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AID-JUNCT study: GIP\/GLP-1RA as Adjunctive to Automated Insulin Delivery - Diabetes Center Berne<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dcberne.com\/en\/project\/aid-junct-study-gip-glp-1ra-as-adjunctive-to-automated-insulin-delivery-in-type-1-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AID-JUNCT study: GIP\/GLP-1RA as Adjunctive to Automated Insulin Delivery - Diabetes Center Berne\" \/>\n<meta property=\"og:description\" content=\"Findings from a prospective, randomized clinical studyInnovative approaches to combination therapy in type 1 DiabetesGlycemic control in type 1 diabetes (T1D) remains a challenge, with ~32% of adults in Switzerland achieving an A1c target of &lt;7%. 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