{"id":13513,"date":"2025-10-16T13:16:24","date_gmt":"2025-10-16T13:16:24","guid":{"rendered":"https:\/\/www.dcberne.com\/?page_id=13513"},"modified":"2026-06-01T09:12:39","modified_gmt":"2026-06-01T09:12:39","slug":"focus-area-insulin-activity","status":"publish","type":"page","link":"https:\/\/www.dcberne.com\/en\/focus-area-insulin-activity\/","title":{"rendered":"Focus Area &#8211; Insulin Activity"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;1px||0px||false|false&#8221; custom_margin_tablet=&#8221;1px||0px||false|false&#8221; custom_margin_phone=&#8221;3px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; border_width_top=&#8221;0.5px&#8221; border_color_top=&#8221;#505358&#8243; border_width_bottom=&#8221;0.5px&#8221; border_color_bottom=&#8221;#505358&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.19.4&#8243; 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custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|hover&#8221; button_text_color__hover=&#8221;#89bbe5&#8243; button_bg_color__hover_enabled=&#8221;on|desktop&#8221; button_bg_color__hover=&#8221;#FFFFFF&#8221; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;80px||0px||false|false&#8221; custom_padding_tablet=&#8221;80px||0px||false|false&#8221; custom_padding_phone=&#8221;48px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row custom_padding_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||40px||false|false&#8221; custom_margin_tablet=&#8221;0px||40px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_padding_tablet=&#8221;0px||40px||false|false&#8221; custom_padding_phone=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_css_main_element=&#8221;margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;64px&#8221; text_line_height=&#8221;70px&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;0px|-107px|0px||false|false&#8221; custom_padding=&#8221;0px||24px||false|false&#8221; text_font_size_tablet=&#8221;64px&#8221; text_font_size_phone=&#8221;42px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; text_line_height_tablet=&#8221;70px&#8221; text_line_height_phone=&#8221;48px&#8221; text_line_height_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Exploring how real-world conditions impact insulin activity<\/h1>\n<div><\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#E1E3E8&#8243; background_image=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/10\/EASD-2025.png&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_css_main_element=&#8221;height: 300px;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;24px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"font-weight: 400;\"><span>Insulin is an essential medication for people living with diabetes (PwD). What truly matters is whether insulin remains active during treatment \u2013 able to bind to its receptor and regulate blood sugar levels. At DCB, we investigate how storage and handling influence insulin activity, aiming to shed light onto this hidden factor in diabetes management.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;https:\/\/www.dcberne.com\/en\/contact\/&#8221; button_text=&#8221;Contact us&#8221; button_alignment=&#8221;right&#8221; button_alignment_tablet=&#8221;left&#8221; button_alignment_phone=&#8221;left&#8221; button_alignment_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;18px&#8221; button_text_color=&#8221;#89bbe5&#8243; button_border_width=&#8221;1px&#8221; button_border_color=&#8221;#89bbe5&#8243; button_border_radius=&#8221;100px&#8221; button_font=&#8221;Calibro Bold||||||||&#8221; button_use_icon=&#8221;off&#8221; 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locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|tablet&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: row;||align-items: center;||gap: 32px;&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221; custom_css_main_element=&#8221;margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;margin-bottom: 32px;||order: -1 !important;&#8221; custom_css_main_element_tablet=&#8221;margin-bottom: 0px;&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/10\/insulin-challenges.png&#8221; alt=&#8221;A bottle of insulin that is affected by several factors such as light, movement, and heat&#8221; title_text=&#8221;insulin-challenges&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/09\/times-study-overview-transparent.png&#8221; background_enable_video_mp4=&#8221;off&#8221; height_tablet=&#8221;&#8221; height_phone=&#8221;222px&#8221; height_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||40px||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_padding_phone=&#8221;0px||0px||false|false&#8221; custom_padding_last_edited=&#8221;off|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover_enabled=&#8221;off|desktop&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;vertically-centered&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;||margin-top: 32px;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||14px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>The challenge<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"font-weight: 400;\">Insulin therapy assumes that every injection works as intended. Yet, insulin is a protein and sensitive to its environment. Heat, light, and agitation<span>\u00a0<\/span>can alter its structure \u2013 and with it, its biological activity.<\/p>\n<p style=\"font-weight: 400;\">Currently, most methods measure\u00a0<strong>how much insulin is present<\/strong>, but not\u00a0<strong>whether it is still active<\/strong>. This knowledge gap leaves patients, healthcare providers, and industry without reliable insights into insulin\u2019s real-life performance.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; module_class=&#8221;text-image-video&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FAFAFA&#8221; custom_margin=&#8221;64px||||false|false&#8221; custom_margin_tablet=&#8221;100px||||false|false&#8221; custom_margin_phone=&#8221;100px||||false|false&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding=&#8221;80px||80px||false|false&#8221; custom_padding_tablet=&#8221;64px||64px||false|false&#8221; custom_padding_phone=&#8221;24px||24px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: row;||align-items: center;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|tablet&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: row;||align-items: center;||gap: 32px;&#8221;][et_pb_column type=&#8221;4_4&#8243; module_class=&#8221;vertically-centered&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;||margin-top: 32px;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center;\">Our Research Focus<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"font-weight: 400; text-align: center;\">We investigate\u00a0<strong>insulin activity under real-world conditions\u00a0<\/strong>to:<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;1140px&#8221; custom_margin=&#8221;40px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_3_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"font-weight: 400; text-align: center;\"><strong><span>Identify stress factors<\/span><\/strong><\/h3>\n<p style=\"font-weight: 400; text-align: center;\">that reduce activity<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_3_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"font-weight: 400; text-align: center;\"><strong><span>Develop reference methods<\/span><\/strong><\/h3>\n<p style=\"font-weight: 400; text-align: center;\">to measure activity loss<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_3_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"font-weight: 400; text-align: center;\"><strong><span>Build the scientific foundation<\/span><\/strong><\/h3>\n<p style=\"font-weight: 400; text-align: center;\">for future monitoring tools and improved therapies<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; module_class=&#8221;text-image-video&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; custom_margin=&#8221;48px||||false|false&#8221; custom_padding=&#8221;64px||64px||false|false&#8221; custom_padding_tablet=&#8221;40px||40px||false|false&#8221; custom_padding_phone=&#8221;24px||24px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: row;||align-items: center;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|tablet&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: row;||align-items: center;||gap: 32px;&#8221;][et_pb_column type=&#8221;4_4&#8243; module_class=&#8221;vertically-centered&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;||margin-top: 32px;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Methods &amp; Approach<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>To quantify insulin activity under real-world stress, we combine functional bioassays with state-of-the-art structural analyses:<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;24px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/10\/functional-readouts-1.png&#8221; title_text=&#8221;functional-readouts&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;100px&#8221; custom_css_free_form=&#8221;selector img {||  aspect-ratio: auto !important;||}&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_3_font=&#8221;Calibri Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"font-weight: 400; text-align: left;\"><strong><span>Functional readouts<\/span><\/strong><\/h3>\n<p style=\"font-weight: 400;\">Quantifying the biological activity of insulin via receptor activation and downstream signaling.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/10\/structural-characterization.png&#8221; title_text=&#8221;structural-characterization&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;100px&#8221; custom_css_free_form=&#8221;selector img {||  aspect-ratio: auto !important;||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_3_font=&#8221;Calibri Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"font-weight: 400; text-align: left;\"><strong><span>Structural characterization<\/span><\/strong><\/h3>\n<p style=\"font-weight: 400;\">Using advanced (bio)analytical tools to determine the 3D structure of insulin and insulin\u2013insulin receptor interaction dynamics.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;100px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: row;||align-items: center;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|tablet&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: row;||align-items: center;||gap: 32px;&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221; custom_css_main_element=&#8221;margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;margin-bottom: 32px;||order: -1 !important;&#8221; custom_css_main_element_tablet=&#8221;margin-bottom: 0px;&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/10\/dcb-doctors.jpg&#8221; alt=&#8221;a group of doctors&#8221; title_text=&#8221;dcb-doctors&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/09\/times-study-overview-transparent.png&#8221; background_enable_video_mp4=&#8221;off&#8221; height_tablet=&#8221;&#8221; height_phone=&#8221;222px&#8221; height_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||40px||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_padding_phone=&#8221;0px||0px||false|false&#8221; custom_padding_last_edited=&#8221;off|phone&#8221; custom_css_free_form=&#8221;selector img {||  aspect-ratio: auto !important;||}&#8221; border_radii=&#8221;off|80px||80px|&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover_enabled=&#8221;off|desktop&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;vertically-centered&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;||margin-top: 32px;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||14px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"font-weight: 400;\">Why Our Research Matters<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"font-weight: 400;\">A deeper understanding of insulin activity will:<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Improve\u00a0<strong>treatment safety<\/strong>\u00a0by ensuring reliable dosing<\/li>\n<li>Reduce\u00a0<strong>uncertainty<\/strong>\u00a0caused by degraded insulin<\/li>\n<li>Enable\u00a0<strong>new technologies<\/strong>\u00a0for drug stability testing<\/li>\n<li>Support\u00a0<strong>patients and healthcare providers<\/strong>\u00a0with actionable knowledge<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; 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module_class=&#8221;vertically-centered&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; custom_css_main_element=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|phone&#8221; custom_css_main_element_phone=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;||margin-top: 32px;&#8221; custom_css_main_element_tablet=&#8221;display: flex;||flex-direction: column;||justify-content: center;||margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center;\">Collaboration<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center;\">The <strong>Insulin Activity focus area<\/strong> at DCB brings together researchers, clinicians, and patient representatives. Through collaborations with academia and industry, we aim to establish new standards for understanding and safeguarding insulin therapy.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_5,1_5,1_5,1_5,1_5&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;16px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.dcberne.com\/wp-content\/uploads\/2025\/11\/5-scaled.png&#8221; title_text=&#8221;5&#8243; align=&#8221;center&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_css_free_form=&#8221;selector img {||  aspect-ratio: auto !important;||}&#8221; 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_module_preset=&#8221;default&#8221; text_font=&#8221;Avant Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;37px&#8221; text_line_height=&#8221;37px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||10px||false|false&#8221; custom_padding_tablet=&#8221;0px||18px||false|false&#8221; custom_padding_phone=&#8221;||16px||false|false&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; custom_css_free_form=&#8221;@media all and (max-width: 1300px) {||  selector {||    margin-top: 10px!important;||  }||}&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Publications &amp; Scientific Output<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Our research on insulin activity is continuously generating new insights. Below is a selection of key outputs and upcoming contributions:<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221; custom_css_main_element=&#8221;margin-bottom: 0px;&#8221; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;off|desktop&#8221; custom_css_main_element_phone=&#8221;||&#8221; custom_css_main_element_tablet=&#8221;margin-bottom: 0px;&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#505358&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Ballhausen H, Braune K, Heinemann L, Schinz M. Real-World Experience With Insulin Activity Among People With Type 1 Diabetes: Results of a Multinational Survey. JDST. 2025. <a href=\"https:\/\/doi.org\/10.1177\/19322968251403527\">https:\/\/doi.org\/10.1177\/19322968251403527<\/a><\/li>\n<li>Heinemann L, Dobitz S, Schinz M. Metabolic Activity of Insulin and Temperature Exposure in the Real World: Challenges for People Living With Diabetes. JDST. 2026.<br \/><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/19322968261423208\">https:\/\/journals.sagepub.com\/doi\/10.1177\/19322968261423208<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; link_font=&#8221;Calibro Bold||||||||&#8221; link_text_color=&#8221;#89bbe5&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/www.dcberne.com\/en\/offering\/\">Research &#8211; Diabetes Center Berne<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#878787&#8243; 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_module_preset=&#8221;default&#8221; text_font=&#8221;Calibri Regular||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;22px&#8221; header_2_font=&#8221;Avant Regular||||||||&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center;\">Join us in shaping the future of insulin therapy.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;mailto:maren.schinz@dcberne.com&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Contact us&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;18px&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_border_width=&#8221;1px&#8221; button_border_color=&#8221;#FFFFFF&#8221; button_border_radius=&#8221;100px&#8221; button_font=&#8221;Calibro Bold||||||||&#8221; 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